Get on our list for Authentic Italian Restaurant and cooking in Fleming Island, Orange Park, Jacksonville Florida. Bruno Santioni is BACK at Santioni's in Fleming Island, FL! Santioni's Italian Restaurant prepares authentic homemade style italian food - old world family recipes from the northern and southern regions of Italy. Home made garlic bread, pasta, pizza, grilled chops, salads, veal dinners, chicken dinners, seafood dinners, calzones, and kids meals are on their new menu. Soon to come, vegan dinner meals and gluten free pastas. A large selection of fine wines are also available. Located at 3535 Highway 17, Fleming Island, FL 32003. Call ahead (904) 264-1331 for Italian take out orders. Take out can be picked up at our drive thru window.